Mario Party for the Nintendo 64 was a multi-player based series of mini-games that spawned a sub franchise for the Mario franchise. Though it is considered a good game, many of the mini-games required heavy rotation of the Nintendo 64's analog stick to win.
Due to the uncomfortable design of the analog stick, many gamers used their palms to play these games. This caused many gamers to get blisters, friction burns, and lacerations on their hands.
Fortunately for Nintendo, no one filed a lawsuit against them but there were over 90 complaints because of this to the New York attorney general's office. Nintendo of America paid $75,000 to the state's legal fees and offered gaming gloves to everyone who got injured. Since it was estimated that 1.2 million users had the game, Nintendo's expenses for the gloves was up to $80,000,000.
Nintendo did learn its lesson from the experience and since Mario Party 2, the analog stick has been used sparingly and by the time of the Gamecube, Nintendo's analog sticks have gotten much more comfortable to use. However, because of the experience, Nintendo has yet to release Mario Party for the Virtual Console.